Atypical Protein Kinases (aPKs)

Atypical Protein Kinases (aPKs) Supplemental Online Material for Manning et al (Science 298:1912-1934) Atypical protein kinases lack sequence similarity to the ePK domain HMM profile, but have been shown experimentally to have protein kinase activity, or are clear homologs of aPKs with ...

Evolution of protein kinase signaling from yeast to man

TRENDSin Biochemical Sciences Vol.27 No.10 October 2002 514 Review 0968-0004/02/$ - see front matter © 2002 Elsevier Science Ltd.

A Specific Inhibitor of Phosphatidylinositol 3=Kinase ...

THE JOURNAL OF BIOIGGICAL CHEMISTRY 0 1994 by The American Society for Biochemistry and Molecular Biology, Inc. Vol. 269, No. 7, Issue of February 18, pp. 5241-5248, 1994 Printed in U.S.A.

Targeting cancer with small molecule kinase inhibitors

Kinases have become one of the most intensively pursued classes of drug target with approximately 30 distinct kinase targets being developed to the level of a Phase I clinical trial.

Tyrosine Kinases as Targets for Cancer Therapy

A tyrosine kinase created by fusion of the PDGFA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereo-sinophilic syndrome. N Engl J Med 2003; 348:1201-14.

s I I. Proteinkinase structure I I I. Proteinkinase activatio ...

1 Protein Kinase Structure, Activation, and Inhibition Alyssa Wu PHAR/BIOM 230 November 21, 2008 I. Background What protein kinases do On a molecular level On a cellular level Classification and phylogeny Regulation of protein kinases II.

A Homogeneous Phosphoinositide 3-Kinase Assay on Phospholipid ...

2 PerkinElmer Life Sciences Abstract Introduction Phosphoinositide 3-kinases (PI 3-kinase) consist of a family of lipid kinases that regulate major pathways by which biological signaling systems operate to control cell functions.

Role of the PI3-Kinase and ERK Pathways in the Induction of ...

Role of the PI3-Kinase and ERK Pathways in the Induction of HIF-1 Activity and the HIF-1 Target VEGF in Ovarian Granulosa Cells in response to Follicle Stimulating Hormone*

Kinase Inhibitor Databases

Kinase Inhibitor Databases Chemical Biological and Pharmacological Information of Kinase Inhibitors from International Journals, US and International Patents have been curated and a unique database is now available in various formats like in ISIS/Base DB, SD, XML and Oracle.

The Kinetic Mechanism of Phosphomevalonate Kinase*

The Kinetic Mechanism of Phosphomevalonate Kinase* Received for publication, October 15, 2002, and in revised form, November 5, 2002 Published, JBC Papers in Press, November 6, 2002, DOI 10.1074/jbc.M210551200

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